PHARMACOKINETICS OF ATRACURIUM IN ACUTE HEPATIC FAILURE (WITH ACUTE RENAL FAILURE)
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چکیده
منابع مشابه
Pharmacokinetics of atracurium in acute hepatic failure (with acute renal failure).
The pharmacokinetic profile of atracurium was examined in six patients with acute hepatic and renal failure and compared with that in six normal patients after an i.v. bolus (mean dose 0.7 mg kg-1). The plasma concentrations were measured by high pressure liquid chromatography and the data fitted to a two-compartment pharmacokinetic model. The results from the two groups were not significantly ...
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SIGNIFICANT renal insufficiency is found in 75% of patients dying from liver failure. Whether the liver failure is due to an acute illness (such as fulminant hepatitis) or chronic disease (such as cirrhosis) the occurrence of renal failure carries a grave prognosis (Shear, Keinerman and Gabuzda, 1965; Wilkinson, Blendis and Williams, 1974) and in a survey of 471 patients with cirrhosis, renal f...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1983
ISSN: 0007-0912
DOI: 10.1093/bja/55.12.1169